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Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology.

SenGupta T, Palikaras K, Esbensen YQ, Konstantinidis G, Galindo FJN, Achanta K, Kassahun H, Stavgiannoudaki I, Bohr VA, Akbari M, Gaare J, Tzoulis C, Tavernarakis N, Nilsen H. . Thompson MG, et al. N Engl J Med. 2021 Sep 8:NEJMoa2110362. doi: 10.1056/NEJMoa2110362. Online ahead of print. N Engl J Med. 2021. PMID: 34496194 . Ishikura Y, et al. Cell Stem Cell. 2021 Sep 1:S1934-5909(21)00342-8. doi: 10.1016/j.stem.2021.08.005. Online ahead of print. Cell Stem Cell. 2021. PMID: 34496297 .

What factors should influence the dosage and interval of prophylactic treatment in patients with severe haemophilia A and B?

Petrini P. Petrini P. .

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